De Jong, who has netted seven times in the Dutch top-flight this season, is fit to travel to Germany after an ankle problem kept him out of the defeat at CSKA Moscow in their previous Group B game.
Fellow Dutch international Jeffrey Bruma is a doubt for Wednesday's match because of a calf injury but midfielder Maxime Lestienne will miss out again.
The Belgian-born Lestienne has been given some time off following the death of his mother.
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Lestienne, who was made a positive impact since arriving from Genoa at the start of the season, has missed PSV's last two games. PSV won their opening Group B match against Manchester United but then lost 3-2 at CSKA.
(Reporting by Mark Gleeson; Editing by Tony Jimenez; mark.gleeson@thomsonreuters.com; +27828257807; Reuters Messaging: Reuters Messaging: mark.gleeson.thomsonreuters.com@reuters.net)
