Leguizamon missed the 57-22 loss to championship leaders New Zealand in Hamilton last week with a leg injury but returns to face the Wallabies at Perth Oval.
Coach Daniel Hourcade was forced into making two changes to his side because of injuries to centre Juan Martin Hernandez and lock Guido Petti against the All Blacks.
Santiago Gonzalez Iglesias replaces Hernandez at inside centre alongside Matias Moroni, who moves in from the wing to complete the midfield partnership.
Lucas Gonzalez Amorosino comes in for Moroni out wide, while centre Matias Orlando drops to the bench.
Javier Ortega Desio, who stood in for Leguizamon in the back row last week, moves to lock in place of Petti.
Hourcade also dropped scrumhalf Martin Landajo to the bench to allow Tomas Cubelli, who plays his Super Rugby in Australia with the ACT Brumbies, a first start since last year's World Cup.
Team: 15-Joaquin Tuculet, 14-Santiago Cordero, 13-Matias Moroni, 12-Santiago Gonzalez Iglesias, 11-Lucas Gonzalez Amorosino, 10-Nicolas Sanchez, 9-Tomas Cubelli, 8-Facundo Isa, 7-Juan Manuel Leguizamon, 6-Pablo Matera, 5-Matias Alemanno, 4-Javier Ortega Desio, 3-Ramiro Herrera, 2-Agustin Creevy, 1-Nahuel Tetaz Chaparro.
Replacements: 16-Julian Montoya, 17-Lucas Noguera, 18-Enrique Pieretto, 19-Marcos Kremer, 20-Leonardo Senatore, 21-Martin Landajo, 22-Gabriel Ascarate, 23-Matias Orlando
(Reporting by Nick Mulvenney; Editing by Amlan Chakraborty)
