The prolific Vardy is also in the race for the golden boot awarded to the league's top scorer, having netted 24 goals so far, one behind his international team mate Harry Kane of Tottenham Hotspur with one round of matches remaining on Sunday.
Leicester visit last season's champions Chelsea, while Spurs travel to relegated Newcastle United.
The 29-year-old's Vardy's phenomenal form this season led to him winning his first England cap and he is certain to be included on Monday in Roy Hodgson's squad for next month's European Championship in France.
News that makes sense
Your trusted source for staying up-to-date with the world around you. Get free daily news updates and analysis, straight to your inbox.
Vardy beat Leicester team mates Riyad Mahrez, N'Golo Kante, Kasper Schmeichel and Wes Morgan, as well as Spurs trio Kane, Dele Alli and Toby Alderweireld, Arsenal's Mesut Ozil and West Ham United's Dimitri Payet for the Premier League award.
He was also voted Player of the Year by the Football Writers' Association (FWA), an award he received at a dinner in London on Thursday attended by manager Claudio Ranieri.
Vardy was named in the Professional Footballers' Association (PFA) team of the year but Leicester's Algeria international winger Mahrez won the PFA Player of the Year award.
(Reporting by Shravanth Vijayakumar in Bengaluru; editing by Ken Ferris)
