Barcelona visit Eibar on Sunday (1500 GMT) with an eight-point lead over Atletico Madrid at the top of standings with 11 matches to go.
They take a 2-0 lead into the home leg of their Champions League last-16 tie against Arsenal next week and face Sevilla in the King's Cup final on May 22.
For Luis Enrique, all the hard work during the season had brought them to this point.
“Now is when the nicest part of the season starts, you are where you wanted from the beginning, fighting for titles,” Luis Enrique said after Thursday’s 5-1 away win over Rayo Vallecano.
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“Then we must see what we achieve. For now, I’m pleased with how the season has progressed, all the work that has brought us here.
“(There is) attitude, intensity and finishing. When Barca manages to be like that you create danger from the first minute and it’s hard to stop them,” he told reporters.
His prolific front three of Lionel Messi, Neymar and Luis Suarez have scored a combined 62 goals in La Liga after Messi notched a hat-trick on Thursday.
Atletico, who visit Valencia on Sunday (1930), have not given up the title chase, however bleak their chances seem.
Diego Simeone’s side have won four and drawn one of their last five matches. Their 1-0 derby win the Bernabeu last weekend left Real Madrid 12 points adrift in third.
Real, who are at home to Celta Vigo on Saturday (1500), have been troubled by injury and fitness woes but central defender Pepe was full of praise for the team’s commitment as they try to put the derby defeat behind them.
“We made a huge effort, the team worked very hard, from the goalkeeper to Borja Mayoral. We stood up, the fans demand work and that’s what we did ... sweat our shirts,” said the captain, who returned from a long injury absence at Levante on Wednesday where Real won 3-1.
Coach Zinedine Zidane has had a good response from a clutch of young players promoted from the junior ranks including striker Mayoral, who stood in for the injured Karim Benzema.
Midfielder Luka Modric (ankle) and left back Marcelo (muscle fatigue) were also back in training on Thursday and could return in Vigo.
(Reporting by Rex Gowar; Editing by Peter Rutherford)
