Asked about the 21-month sentence, which is currently suspended, Luis Enrique told a news conference: "I don't think it will affect Leo but he is the only one that can reply to that."
Messi announced his international retirement after missing a penalty in the Copa America final shootout.
He has now lost Copa America finals in 2007, 2015 and 2016 and also the 2014 World Cup final. His Olympic gold medal in 2008 is his only major international honour.
But Luis Enrique did not sound convinced that Messi's international retirement would be permanent.
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"He said it at a difficult time," he said. "Only time will tell if he will continue or not with Argentina. As a fan, I would like him to continue to play for Argentina but from a selfish standpoint, I'm open to any possibility."
He added: "Messi will arrive as always with enthusiasm to play because what he likes most is football," he said. "This summer he deserved to win the Copa America but in football, sometimes the team that plays better doesn't win."
The Barcelona boss has lost Brazilian right back Dani Alves, who signed for Juventus after leaving as a free agent this summer. "We will miss him," he said.
But he expects Javier Mascherano -- also a Juventus target -- who is under contract until June 2018, to stay put.
"I hope that Mascherano's (contract) renewal is completed soon," he said. "I believe that will be the case. He is vital, key for our system, on and off the pitch."
However, Luis Enrique expects great things from Turkey midfielder Arda Turan, who joined Barca last summer from Atletico Madrid but only made his debut in January 2016 due to a transfer embargo on the club.
Turan found it difficult to earn a starting place, with just two goals in nine league games.
"The first year is always difficult," he said. "I fully trust Arda. Last year, he gave a lot and this year, his level will go up. I'm certain."
(Reporting by Adriana Garcia,; Editing by Neville Dalton)
