Miami Dolphins have produced a brilliant last-gasp touchdown to beat New England 34-33 in the NFL and prevent the Patriots clinching a 10th successive AFC East title.
Miami went 69 yards with the last action of the game for a touchdown that included two lateral passes.
Kenyan Drake was the last recipient and secured a dramatic victory that overshadowed Tom Brady's latest record-breaking performance.
The Patriots quarterback surpassed Peyton Manning's mark of 579 touchdown throws with his first of three scoring passes in the first half.
Kansas City Chiefs clinched a play-off place as they produced some late drama of their own to earn a 27-24 overtime victory against the Baltimore Ravens.
The Chiefs were facing defeat with 89 seconds left and had a fourth and nine to convert but quarterback Patrick Mahomes brilliantly connected with Tyreek Hill to extend the drive and it led to a Damien Williams touchdown.
The Chiefs defence forced a turnover but Harrison Butker missed from 43 yards with a potential game-winning field goal.
Butker redeemed himself with a 35-yard field goal in overtime to secure an 11th win of the season.
New Orleans Saints clinched back-to-back NFC South titles and their place in the post season with a come-from-behind 28-14 victory against the Tampa Bay Buccaneers.
The Saints trailed 14-3 at halftime but they scored 25 unanswered points.
Houston Texans had their nine-match winning streak end at the hands of AFC South rivals the Indianapolis Colts 24-21.
Dallas Cowboys extended their lead at the top of the NFC East with a 29-23 overtime win against division rivals the Philadelphia Eagles, their fifth win in a row putting has them two-games clear of the Supr Bowl champions.
Green Bay Packers beat the Atlanta Falcons 34-20 with Aaron Rodgers setting an NFL record for the most consecutive completed passes without an interception.
Michael Badgley kicked four field goals, including a team-record 59-yarder, as the Los Angeles Chargers held off the Cincinnati Bengals 26-21.
Carolina Panthers suffered a fifth-straight defeat as they lost 26-20 to the Cleveland Browns, New York Giants thrashed the Washington Redskins 40-16 and the New York Jets beat the Buffalo Bills 27-23.
Detroit Lions beat the Arizona Cardinals 17-3 while the San Francisco 49ers defeated the Denver Broncos 20-14.
