Mitchell Starc has been taken to hospital in an ambulance after cutting his leg in a training mishap in Sydney.
Starc ran into a piece of training equipment on Thursday during a fielding session. Team doctor John Orchard, who was watching training, accompanied Starc in the ambulance.
The left-armer and Josh Hazlewood had already been rested from the upcoming ODI tour of South Africa.
Hazlewood and Starc weren't expected to take part in the domestic one-day competition until the national squad returned from South Africa in mid-October.
Meanwhile, allrounder James Faulkner and batsman Shaun Marsh have both been ruled out of the five-match ODI series that starts on September 30.
Marsh is still recovering from a broken finger, while Faulkner tweaked his calf on Thursday.
Usman Khawaja has been added to the squad as Marsh's replacement.
"Shaun undertook a follow up x-ray and was reviewed by specialists this week. Unfortunately due to the fracture being in the joint of the finger we have decided to take a more conservative approach," team physio David Beakley said.
"James suffered a low-grade calf strain during a fitness session in Sydney today which we expect to take three-four weeks to recover. Unfortunately this means he will also be unavailable for the South Africa series."
