Tigres overcame Santos Laguna in the first semi-final on Wednesday.
Sporting Kansas City lost the first leg of the semi-final 5-0 in Mexico last week but they got the start they wanted with a goal from Gerso Fernandes after just five minutes.
However, Rogelio Funes Mori evened the score with a cool finish 15 minutes later and although Fernandes put the home side ahead again, man-of-the-match Rodolfo Pizarro equalised again for Monterrey six minutes before half time.
Ilie Sanchez missed a penalty for the home side on the stroke of half time and then Miguel Layun put Monterrey ahead for the first time after 62 minutes with a stunning free-kick from 30 meters out.
Aviles Hurtado made it 4-2 for Monterrey eight minutes from time and then Funes Mori got his second in stoppage time to seal a convincing victory.
(Reporting by Andrew Downie; editing by Amlan Chakraborty)