Manu Tuilagi will miss the rest of the rugby season with a knee injury, ruling the injury-plagued centre out of the England's Six Nations title defence.
His club side Leicester have confirmed Tuilagi tore a ligament in Sunday's domestic Premiership game against Saracens.
The 25-year-old Tuilagi has had severe groin trouble over the last two years and only managed one appearance for England in 2016.
Leicester said Tuilagi is facing a six-month recovery period so is likely to be out of contention for the British and Irish Lions tour of New Zealand in June and July.
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