Scientists believe they have made a breakthrough in treating schizophrenia by helping patients train themselves to control verbal hallucinations using an MRI scanner and a computer game.
A pilot study by researchers at King's College London's Institute of Psychiatry, Psychology & Neuroscience (IoPPN) and the University of Roehampton has suggested the new technique can help patients who experience hallucinations but do not respond to medication.
They said their research shows sufferers can learn mental strategies to help ease their symptoms.
The study, which is published in the journal Translational Psychiatry, involved 12 patients who experienced verbal hallucinations on a daily basis.
Around 70 per cent of people with schizophrenia hear voices, which can cause a high level of distress and disruption to daily life, and medication is ineffective for around 30 per cent of patients in treating these verbal hallucinations.
Brain imaging experts targeted a region of the brain which is sensitive to speech and human voices, and is hyperactive in people with schizophrenia and verbal hallucinations.
They designed a "neurofeedback" technique, where patients in a MRI scanner could monitor their own neural activity in the speech sensitive region of the brain.
Neural activity was represented by a computerised space rocket, and patients were instructed to land the rocket by bringing it down to earth.
No explicit instructions were given to patients about how to move the rocket, instead patients were asked to develop their own mental strategies to move it.
After four visits to the MRI scanner, patients were able to reduce neural activity in the speech sensitive region of the brain and were able to control their brain activity without the visual feedback from the space rocket.
After training, patients had learned lasting strategies which they could apply during their daily lives.
Researchers said it is the first time neurofeedback techniques have been investigated for schizophrenia and verbal hallucinations.
Dr Natasza Orlov, of King's IoPPN, said: "Our study has shown that people with schizophrenia can learn some sort of mental strategy to help their symptoms - something which several years of medication has not helped with."
