The Los Angeles Rams have clinched the NFC West title for the second season in a row with Todd Gurley rushing for 132 yards and two scores in a 30-16 win over the Detroit Lions.
A three-point game going into the fourth quarter, Gurley sealed the win after muscling his way into the end zone with two minutes left on the clock.
Patrick Mahomes threw four touchdowns as the Kansas City Chiefs saw off the Oakland Raiders 40-33.
The Green Bay Packers fired head coach Mike McCarthy as a Mason Crosby missed field goal resulted in a 20-17 defeat to the Arizona Cardinals.
Aaron Rodgers completed 31 of 50 for 233 yards and a touchdown but his 35th birthday was to end in disappointment as Crosby hooked his 49-yard attempt wide as time expired.
Tom Brady passed the 1,000 career rushing yards in his 19th season as the New England Patriots beat the Minnesota Vikings 24-10.
Brady passed for 311 yards and a touchdown as Bill Belichick earned his 250th victory, including playoffs, as Patriots coach.
Josh Allen had two scores and rushed for 135 yards but the Buffalo Bills went down to divisional rivals Miami Dolphins 21-17.
Another AFC East side, the New York Jets, capitulated in Nashville, leading 16-0 but going down 26-22 to the Tennessee Titans to record their sixth loss in a row.
The Jets had a pick-six, blocked a punt and a point after attempt but their defence crumbled in the fourth quarter with Marcus Mariota finding Corey Davis for the game-winning touchdown with 36 seconds left.
Overtime was needed in New Jersey as the New York Giants blew a 10-point lead late in the fourth but salvaged a 30-27 win over the Chicago Bears with an Aldrick Rosas 44-yard field goal.
The Jacksonville Jaguars restricted the Indianapolis Colts to 265 yards in a 6-0 win, while the Houston Texans D-Line forced four turnovers from the Cleveland Browns in their 29-13 victory.
Cam Newton threw for two touchdowns and 300 yards but was picked off four times as the Carolina Panthers went down 24-17 to the Tampa Bay Buccaneers.
The Seattle Seahawks saw off the fading San Francisco 49ers 43-16, the Atlanta Falcons lost 26-16 to the Baltimore Ravens and Denver Broncos kept up their purple patch with a 24-10 win over the Cincinnati Bengals.
In a dramatic end to Sunday's schedule Michael Badgley kicked a 29-yard field goal on the final play to lift the Los Angeles Chargers to a 33-30 victory over the Pittsburgh Steelers.
Badgley initially missed a 39-yard kick but Pittsburgh was called for offsides.
His ensuing 34-yard attempt was blocked, but the Steelers were again flagged jumping across the line of scrimmage before the snap.
He then drilled his third attempt at the game-winner to leave the clinging to the AFC North lead over a surging Baltimore.
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