Oracle founder Larry Ellison has donated $US200 million ($A271 million) to the University of Southern California to fund a cancer research centre.
The figure matching the largest single donation ever received by the school.
The Los Angeles Times reports the university announced Ellison's gift on Wednesday.
The money will fund the Lawrence J. Ellison Institute for Transformative Medicine, which will be built off campus in west Los Angeles.
The institute will be led by professor of engineering and medicine David Agus and will focus on preventing, detecting and treating cancer.
USC President C. L. Max Nikias says Ellison's donation and plans to invest in cancer research have been discussed for over a year.
The university's previous $US200 million donation was from the chairman of a large steel fabricating company, David Dornsife, in 2011.
