Aaron Rodgers has thrown three touchdown passes in the second half as the Green Bay Packers overcame a 20-point deficit for a thrilling 24-23 win over the Chicago Bears.
Rodgers, who was carted off the field in the first half with a knee injury, connected with receiver Randall Cobb for a catch-and-run 75-yard touchdown and the go-ahead score with 2:13min left in the game.
A Chicago defence featuring newly acquired star linebacker Khalil Mack dominated until the third quarter.
Mack had a 27-yard interception return for a touchdown against back-up quarterback DeShone Kizer in the second quarter.
Rodgers returned in the second half and finished 20 of 30 for 286 yards as the Packers recorded a franchise record 17-point fourth-quarter comeback.
Reigning league MVP Tom Brady threw for 277 yards and three touchdowns in the New England Patriot's 27-20 win over the Houston Texans.
Brady and Rob Gronkowski, who both floated the possibility of retiring over the off-season, connected seven times, including a 21-yard touchdown.
Jakeem Grant scored on a tiebreaking 102-yard kickoff return with 14 minutes to go, and the Miami Dolphins overcame two weather delays to win the longest game since the 1970 NFL-AFL merger 27-20 against the Tennessee Titans.
Delays for lightning lasted a total of almost four hours and the game took seven hours, 10 minutes to play.
Cleveland Browns ended their 17-game losing streak on Sunday with a 21-21 tie against the Pittsburgh Steelers
But the Browns missed a chance at their first victory since 2016 when kicker Zane Gonzalez's 43-yard field-goal attempt with nine seconds left in OT was blocked by T.J. Watt - who also had four sacks.
Ryan Fitzpatrick highlighted a 417-yard, four-touchdown performance with two scoring strikes of more than 50 yards as the Tampa Bay Bucaneers overcame the New Orleans Saints 48-40.
Kirk Cousins passed for two touchdowns in his much-anticipated Minnesota debut, and the Vikings forced four turnovers to stick 49ers quarterback Jimmy Garoppolo with his first loss in eight games as an NFL starter - 24-16.
Von Miller sacked Russell Wilson three times, forced two fumbles and recovered one in helping quarterback Case Keenum win his
Alex Smith carved up the Arizona Cardinals defence for 255 yards and two touchdowns in the Washington Redskins' 24-6 win.
Quarterback Cam Newton ran for 58 yards and a touchdown in
In other results, the Denver Broncos beat the visiting Seattle Seahawks 27-24, the Carolina Panthers' defeated the Dallas Cowboys 16-8, the Cincinnati Bengals won 34-23 at the Indianapolis Colts, the Baltimore Ravens crushed the Buffalo Bills 47-3, the Jacksonville Jaguars defeated the New York Giants 20-15 and the Kansas City Chiefs overcame the San Diego Chargers 38-28.
