New England extended their NFL winning streak to eight games with a 23-3 win over the Buffalo Bills while Philadelphia's nine-match victory run was ended by a Russell Wilson-led Seattle.
Running back Rex Burkhead scored a pair of touchdowns for the Patriots to go with Stephen Gostkowski's three field goals before halftime.
Tom Brady completed 21 of 30 passes for 258 yards, while improving to 27-3 over Buffalo and breaking Brett Favre's NFL record for most wins by a quarterback against any one opponent.
The 10-2 Patriots won their 14th successive road game -- the second-longest streak in NFL history -- and reached double-digits in victories for the 15th consecutive season.
Minnesota Vikings (10-2) also claimed their eighth win in a row, with Case Keenum throwing two touchdown passes in their 14-9 win over the Atlanta Falcons.
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Russell Wilson threw three touchdown passes as the Seattle Seahawks stayed in the NFC playoff hunt with a 24-10 victory over the Philadelphia Eagles.
Seattle (8-4) snapped Philadelphia's streak thanks largely to another masterful performance by their quarterback. Wilson threw touchdowns of 11 yards to Jimmy Graham, one yard to Tyler Lockett and another to JD McKissic after the Eagles had trimmed the lead to seven.
Philadelphia (10-2) were the highest-scoring team in the NFL averaging 31.9 points per game. But the Eagles got just 10 points out of seven drives that at some point reached Seattle territory.
Carson Wentz was 29 of 45 passes for 348 yards with one touchdown and one interception.
Tennessee Titans remain at the top of the AFC South after beating the Houston Texans 24-13 for their eighth win of the year.
Calais Campbell made history as the Jacksonville Jaguars (8-4) beat the Indianapolis Colts 30-10, becoming the franchise's single-season sack leader after taking his total to 12.5 in the first quarter.
Joe Flacco threw two touchdown passes in the Baltimore Ravens' 44-20 win over the Detroit Lions while the Green Bay Packers beat the Tampa Bay Buccaneers 26-20 thanks to Aaron Jones's touchdown run in overtime.
Miami Dolphins ended their five-game losing run with a 35-9 victory over the Denver Broncos, condemning their visitors to an eighth-straight loss.
Josh McCown starred as the New York Jets beat the Kansas City Chiefs 38-31 while Robbie Gould returned to haunt his former team as he scored every point for the San Francisco 49ers in their 15-14 win over the Chicago Bears, including a last-gasp field goal.
