Joel Embiid had 32 points and 14 rebounds to lead the Philadelphia 76ers past fellow NBA MVP contender James Harden and the Houston Rockets 121-93.
Philadelphia played without four-time All-Star Jimmy Butler due to a wrist injury, and Embiid more than made up for his absence while Australia's Ben Simmons had nine points and six rebounds.
Harden finished with 37 points - giving him 20 straight games with at least 30.
The 76ers broke the game open in a dominant third quarter as they outscored Houston 29-13 to take a 94-63 advantage into the fourth.
Giannis Antetokounmpo poured in a game-high 31 points as the Eastern conference-leading Milwaukee Bucks secured a 116-106 NBA win against the Dallas Mavericks.
Antetokounmpo also had a team-high 15 rebounds to record his 32nd double-double of the season.
Dallas rookie Luka Doncic recorded his first career triple-double with 18 points, 11 assists and 10 rebounds, joining Philadelphia's Markelle Fultz as the only teenagers in NBA history to post a triple-double.
Chicago led wire to wire for the first time this season in a 104-88 Martin Luther King Jr. Day victory over the Cleveland Cavaliers and Paul George scored a game-high 31 points for the Oklahoma City Thunder, who never trailed in a 127-109 win over the New York Knicks.
Trevor Ariza finished with 20 points and 12 rebounds as the Washington Wizards defeated the Detroit Pistons 101-87 while Evan Fournier and Nikola Vucevic scored 29 points apiece as the Orlando Magic pulled away from the Atlanta Hawks for a 122-103 victory.
D'Angelo Russell had 31 points and eight assists, and the surging Brooklyn Nets won their fourth straight game, 123-94 against the Sacramento Kings.
Kyrie Irving posted his 11th double-double of the season with 26 points and 10 assists, leading the host Boston Celtics to a 107-99 win over the Miami Heat; the New Orleans Pelicans beat the Grizzlies 105-85 without injured star Anthony Davis.
Klay Thompson scored 23 of his 44 points in the third quarter, setting an NBA record by connecting on his first 10 3-point attempts of the game, and the visiting Golden State Warriors extended their winning streak to eight games with a 130-111 victory over the Los Angeles Lakers.
Thompson went 3-for-3 from 3-point range in the first half before hitting his first seven attempts from behind the arc in the third quarter.
He wound up 10 of 11 from long distance on the night.
The four-time All-Star finished with his 13th career game of at least 40 points and made 10 or more 3-pointers for the fifth time in his career.
The Utah Jazz went down at home to the Portland Trail Blazers 109-104.
