Pliskova, who sent down 33 winners and seven aces en route to winning her third title of the year, said she was pleased at the level she had reached ahead of Wimbledon.
"All week I was playing quite perfect tennis and didn't drop a set," Pliskova said. "Angelique for sure is one of the best grass court players. It's my third final and in two of them I have won. I just enjoy myself here."
It was a third consecutive defeat in an Eastbourne final for Kerber, who nonetheless heads into Wimbledon after a solid grass court campaign.
The German will face compatriot Tatjana Maria in her first match at Wimbledon on Tuesday, while Pliskova takes on China's Zhu Lin on Monday.
(Reporting by Hardik Vyas in Bengaluru; Editing by Christian Radnedge)
