World number one Nadal and Federer, who could meet in the semi-finals, will not be bothered as they are scheduled on the roof-covered centre court against Dusan Lajovic and Frances Tiafoe respectively, with the Swiss closing the night session.
World number one Karolina Pliskova opens proceedings on the main showcase court against Magda Linette, of Poland, before defending champion Angelique Kerber, seeded sixth, takes on talented Japanese Naomi Osaka.
Canadian Eugenie Bouchard, who is suing the U.S. Tennis association after suffering concussion in a fall on a locker room floor last year, plays Russian Evgeniya Rodina on Grandstand.
Former champion Juan Martin Del Potro is on Louis Armstrong against Swiss Henri Laaksonen before an all-Australian clash between Nick Kyrgios and John Millman.
News that makes sense
Your trusted source for staying up-to-date with the world around you. Get free daily news updates and analysis, straight to your inbox.
(Reporting by Julien Pretot,; Editing by Neville Dalton)
