"I have tried everything in my power to rehabilitate this injury in time for the U.S. Open ... However, I am left with no option but to withdraw from the event," Raonic said on Instagram.
"I have too much respect for the U.S. Open and my fellow competitors to take a spot in the draw when I know I cannot give full effort due to this injury."
The 26-year-old said he had a procedure to alleviate the condition in his left wrist and is undergoing rehabilitation to recover over the next few weeks. He hoped to return to the ATP Tour later this year.
Several other top players will miss the U.S. Open due to injury with Novak Djokovic (elbow), Stan Wawrinka (knee) and Kei Nishikori all ending their season early to recover.
The U.S. Open, the final grand slam of the year, is being held from Aug. 28 to Sept. 10 in New York.
(Reporting by Aditi Prakash in Bengaluru; Editing by Peter Rutherford)
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