"It's not simply a case of would you like to do it, because as a Mancunian, of course I would and everybody had a great day at the Etihad. But the Union has demands on its finances," Cosslett told British media.
Despite widespread support for the idea, the RFU has confirmed there are no plans to stage home England tests away from Twickenham.
"The record investment we've been able to put into the game is because we've got financial stability and Twickenham games with 82,000 people are a big contributor to that," Cosslett added.
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"It's a big trade off and at this point we're keeping games at Twickenham.
"It's getting that balance right and understanding the financial implications. The financial impact is significant... It's a big sum of money because there is no stadium in the north of England with 82,000 seats."
(Reporting by Shravanth Vijayakumar in Bengaluru; Editing by John O'Brien)
