The Portuguese forward was jeered throughout the match at the Wanda Metropolitano Stadium, where Atletico got late goals from Uruguayan defenders Jose Gimenez and Diego Godin to take a vital lead into the return leg on March 12.
He responded to the taunts by holding up five fingers to indicate the number of times he had won the competition, four times with arch-rivals Real and once with Manchester United.
Atletico have reached the final of Europe's elite club competition three times but never lifted the trophy.
They lost to Ronaldo's Real Madrid in 2014 and 2016.
News that makes sense
Your trusted source for staying up-to-date with the world around you. Get free daily news updates and analysis, straight to your inbox.
(Reporting by Rohith Nair in Bengaluru; Editing by Peter Rutherford)
