In addition to the match between Ireland and Italy, the U.S. men's team will face the Maori All Blacks, while the U.S. women's team will play New Zealand on the same weekend.
"Irish Rugby is delighted to be returning to Chicago," IRFU Director of Commercial and Marketing Padraig Power said in a statement.
"In 2016 the Ireland team experienced tremendous support and made history in a week that also witnessed the Cubs celebrating their own piece of history on the streets of Chicago.
"We are looking forward to an exciting match against Italy who are a well-coached and dangerous team."
(Reporting by Simon Jennings in Bengaluru, editing by Pritha Sarkar)
