The midfielder got Ronald Koeman's Saints off to a quick start with a goal from a free kick after five minutes and added his second from the penalty spot in the 35th after Matt Targett was fouled.
Dusan Tadic made it 3-0 in the 72nd minute in a game between two sides whose previous clashes had produced few goals.
Eight of the 11 previous Premier League meetings between the two had finished either goalless or 1-0, with just three goals in their most recent five league encounters.
(Reporting by Alan Baldwin, editing by Clare Fallon)
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