Drew Brees had four touchdown passes in the New Orleans Saints' 48-7 NFL drubbing of the Philadelphia Eagles.
The Saints have the joint-best record at 9-1, with their victory over the Super Bowl champions their ninth in a row.
Brees, who completed 22 of 30 passes for 363 yards, drove New Orleans to double-digit scores in each of the four quarters with their offence on song.
Eagles quarterback Carson Wentz was picked off three times and could only muster 156 throwing yards as the Saints defence dominated.
Quarterback Ben Roethlisberger was far from perfect until the fourth quarter and that was enough for the Pittsburgh Steelers in their 20-16 win at the Jacksonville Jaguars.
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One week after Roethlisberger had a perfect quarterback rating, he overcame three interceptions and a 16-0 deficit by leading two late scoring drives for the Steelers (7-2-1).
Justin Reid returned an interception 101 yards to help the Houston Texans overcome the Washington Redskins 23-21 and secure their seventh consecutive victory.
Washington's loss to the Texans (7-3) came at a significant price when quarterback Alex Smith suffered a gruesome ankle injury on a sack in the third quarter, before Redskins kicker Dustin Hopkins missed a 63-yard field-goal attempt with three seconds left.
Dallas Cowboys' Brett Maher shook off a missed extra point to kick a 42-yard field goal on the final play to snatch a 22-19 win over the Atlanta Falcons.
In two other dramatic late finishes, rookie Daniel Carlson kicked a 35-yard field goal on the final play of the game as the Oakland Raiders edged the Arizona Cardinals 23-21 while Brandon McManus kicked a 34-yard field goal as time expired to give the Denver Broncos a 23-22 win over the Los Angeles Chargers.
Andrew Luck threw three touchdown passes and Marlon Mack and Jordan Wilkins both ran for scores as the Indianapolis Colts thumped the Tennessee Titans 38-10.
Tennessee lost quarterback Marcus Mariota in the final minute of the first half after he reinjured his right elbow.
Rookie quarterback Lamar Jackson led the Baltimore Ravens to their first win in four games, 24-21 over the Cincinnati Bengals.
Carolina Panthers quarterback Cam Newton threw an incomplete pass on a two-point conversion with 1:07min left to allow the Detroit Lions to hold on for a 20-19 win.
Saquon Barkley ran for a career-high 142 yards and scored three touchdowns while Eli Manning threw two touchdown passes as the New York Giants beat the Tampa Bay Bucaneers 38-35.
