San Antonio have beaten the Washington Wizards 112-100, making it nine straight NBA wins for Australian Patty Mills' side.
LaMarcus Aldridge led the way for the Spurs with 24 points, while Tony Parker added 20 and Mills, who came off the bench, scored 13 and had four assists.
The Spurs (14-3) swept a three-game road swing and are a perfect 10-0 away from home.
Kawhi Leonard scored 19 for San Antonio, which shot 53.3 per cent (40 of 75) from the field.
The Spurs led by 10 at halftime and as many as 19 in the second half.
San Antonio's bench outscored the Washington reserves 35-18.
Bradley Beal led Washington (5-10) with 25 points and John Wall scored 21 as all five starters finished in double figures.
Marcin Gortat had 10 points and 10 rebounds.
Meanwhile, Kemba Walker scored 28 points as the Charlotte Hornets snapped a four-game losing streak with a 107-102 victory over the New York Knicks.
Russell Westbrook recorded his second straight triple-double and NBA-best seventh of the season with 17 points, 15 assists and 13 rebounds to help the Oklahoma City Thunder beat the Detroit Pistons 106-88.
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