Lock Gray sustained a chest muscle tear in Sunday’s 29-18 win over France while number eight Denton has returned to his club Bath to continue his rehabilitation from the groin injury sustained on the eve of the previous match against Italy.
Flyhalf Finn Russell suffered concussion against France and is still being assessed.
Scotland are bidding for their third successive victory in the tournament on Saturday after finishing bottom of the Six Nations standings last year.
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(Reporting by Ed Osmond, editing by Pritha Sarkar)
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