Seattle Seahawks quarterback Russell Wilson threw three touchdown passes in a 27-3 victory as the Oakland Raiders endured another miserable NFL outing at Wembley.
Four years ago, Oakland head coach Dennis Allen was fired after a one-sided loss to the Miami Dolphins in London and their latest visit proved just as humbling.
Jaron Brown, David Moore and Tyler Lockett were the grateful recipients of Wilson's throws, with Sebastian Janikowski booting the extra points as well as two field goals.
All eyes were on Marshawn Lynch in his first game against Seattle since reversing his retirement decision last year to play for the Raiders.
Lynch was a key component of the Seahawks' Super Bowl-winning team in 2014 but he was on the margins against his former employers, contributing just 45 rushing yards in 13 carries.
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Todd Gurley rushed for two touchdowns and a career-best 208 yards as the visiting Los Angeles Rams held on for a 23-20 victory over the Denver Broncos to improve their league best record to 6-0.
The Rams are the only unbeaten team in the NFL after a 28-yard field goal from Stephen Gostkowski on the last play of the game gave the New England Patriots a 43-40 win over the Kansas City Chiefs.
Patriots veteran Tom Brady threw for one touchdown and rushed for one himself while Chiefs quarterback bounced back from two first-half interceptions to connect on four touchdown throws.
Chicago Bears squandered an 11-point advantage against the Miami Dolphins, who clinched a 31-28 victory courtesy of Jason Sanders' 47-yard field goal in the final moments of overtime.
Cody Parkey had earlier been awry with his kick from six yards further away but Sanders made no mistake as Chicago's three-game winning streak came to an end.
Antonio Brown ran in for a 31-yard touchdown in the final few seconds that sealed a 28-21 victory for Pittsburgh over Cincinnati, the Steelers' eighth win in a row over the Bengals.
Baltimore set a franchise record with 11 sacks and Alex Collins scored two touchdowns as the Ravens shut out the Tennessee Titans 21-0.
Veteran quarterback Philip Rivers threw a couple of touchdown passes to Tyrell Williams to help the Los Angeles Chargers see off the Cleveland Browns 38-14.
Jason Myers set a New York Jets record for successful field goal attempts with seven as they overcame the Indianapolis Colts 42-34.
Dak Prescott threw two touchdown passes to Cole Beasley in the Dallas Cowboys' 40-7 victory over the Jacksonville Jaguars.
Atlanta Falcons snapped a three-game losing streak as Matt Ryan's 354 yards and three touchdowns saw them edge out the Tampa Bay Buccaneers 34-29.
Washington Redskins pipped the Carolina Panthers 23-17, the Houston Texans defeated the Buffalo Bills 20-13 and the Minnesota Vikings overcame the Arizona Cardinals 27-17.
