The Argentine replaces compatriot Jorge Sampaoli, who left to take over the Argentina national team in May.
Berizzo was in charge of La Liga rivals Celta Vigo for three seasons from 2014, leading the Galicians to last season’s Europa League semi-finals, and to eighth and sixth place finishes in his first two years in charge before coming 13th in the last campaign.
The 47-year-old agreed a deal in principle to join Sevilla, who finished fourth last season, earlier this month and put pen to paper on Tuesday.
“My challenge is the same as Sevilla’s: to keep on winning. It’s more difficult to continue winning than to do so for the first time. We’ll look to strengthen as much as we can in order to improve a side that is already very good,” Berizzo said.
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His first competitive game as coach will come in the Champions League play-off round in August.
(Reporting by Joseph Cassinelli; Editing by Alison Williams)
