"He may miss out on Sunday's game. The likelihood is he will probably need at least 10 days possibly more and that's a real shame," Hughes told the club's website (www.stokecityfc.com).
"He's got damage to his hamstring unfortunately after pulling up in training. It's a shame because he's just started to acclimatise to the Premier League and we could have used his guile last night."
After taking a while to find his feet at the club, Shaqiri has become a key member of the squad. Signed for a club record 12 million pound ($17.27 million) in August, he put in strong performances in impressive wins over Manchester City and Everton last month.
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Hughes also said that striker Marko Arnautovic, who has scored seven league goals in 20 appearances, was a slight doubt for the game as he "has been feeling a little bit stiff in his hamstring."
(Reporting by Shravanth Vijayakumar in Bengaluru, editing by Pritha Sarkar)
