City, meanwhile, are currently on a record-breaking 15-game winning streak in the league and 18 points ahead of Tottenham but Pochettino is confident his side can end that dominant run.
"I am so positive. I am a positive person. I am happy for the three points. What happens on Saturday, who knows? We go to Manchester to try to win. Football is football," Pochettino said after Wednesday's 2-0 victory over Brighton and Hove Albion.
"In the last week, we have got three wins, and that is so important for us. We now feel we can stay higher in the table. There is a long way to go in the season and anything can happen.
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"We are going to enjoy the game, as it is a fantastic challenge to play Manchester City. They are the best team in England, and one of the best teams in Europe. I am so excited to play in these games..."
Midfielder Erik Lamela started his first game for Tottenham since October 2016 against Brighton and Pochettino has backed the Argentina international to have a positive impact on the team's performance.
"I think it is so important, he brought fantastic energy to the team and the last few weeks too," Pochettino told reporters.
"It's normal and he needs time to give his best. I think it's so important for the team to have him fit again and I think he's going to help us a lot."
Following the City clash, Tottenham play four league games and an FA Cup match within the space of two weeks.
(Reporting by Aditi Prakash in Bengalaru)
