Sixteen die in US military plane crash

At least 16 people have died after a US military aircraft crashed into a field in rural Mississippi.

A US military plane has crashed into a field in Mississippi killing 16 people. (AAP)

At least 16 people have been killed when a US military plane crashed in rural Mississippi, a regional emergency management official says.

No official details were immediately available on the circumstances of the crash in northern Mississippi's LeFlore County, about 160 kilometres north of Jackson, the state capital, on Monday evening.

Captain Sarah Burns, a spokeswoman for the Marine Corps, said only that a US Marines KC-130 Hercules transport aircraft had "experienced a mishap," with news media initially reporting five confirmed deaths.

Several hours later, Fred Randle, LeFlore County director of emergency management, told Reuters that at least 16 people had perished. Randle gave no further details of the incident.

The incident was a "tragedy", Mississippi Governor Phil Bryant said in a statement on social media site Facebook, but provided no details.

Images posted online by news organisations showed the crumpled wreckage of a plane engulfed in flames in a field surrounded by tall vegetation, with a large plume of smoke in the sky above the crash site.