The team, currently without a coach, will also play two home matches in October, with their opponents to be confirmed at a later date. They will then head to Europe for friendlies against England on Nov. 15 at London's Wembley Stadium and versus Italy on Nov. 20 at a venue yet to be determined.
"We are at the beginning phase of building our identity," national team general manager Earnie Stewart said in a statement.
"These games are obviously huge challenges, and for young players it's an opportunity to see the benchmark of some of the top teams in the world.
"We can use these experiences to learn about ourselves and take the next steps towards developing into the team we want to become."
Bruce Arena resigned as U.S. coach last October after his squad failed to qualify for the World Cup, which ended the Americans' streak of seven consecutive appearances in the global showpiece.
(Reporting by Frank Pingue in Toronto; Editing by Ian Chadband and Peter Graff)