The 2010 World Cup winners will face Costa Rica at Malaga's La Rosaleda stadium on Nov. 11. The Central American nation, who reached the quarter-finals of the 2014 World Cup, have also qualified for the tournament in Russia.
Spain then travel to hosts Russia on Nov. 14 to play at the Krestovsky stadium in Saint Petersburg, which will hold seven games at the World Cup.
Julen Lopetegui's side clinched their place in the showpiece tournament last Friday by beating Albania 3-0.
They finished top of European qualifying Group G by winning nine out of 10 games in the campaign.
(Reporting by Richard Martin; Editing by Toby Davis)
