Pochettino is without long-term absentees Danny Rose (knee) and Erik Lamela (hip) as well as the suspended Dele Alli and Jan Vertonghen but said he would not "cry" about missing players.
"It's true we'll miss Christian but we have to move on. We have a strong squad and we have to find a way to perform well and try to win the game," he told the club's website (www.tottenhamhotspur.com).
"I'm not a manager who will cry because some players cannot play. It's about the team, the squad and a collective effort.
"Of course you always miss players who are injured or ill because you want everyone available. It's a bit of a shame but it's important we deal with that in the best way, try to perform well and try to win."
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The London side beat Germany's Borussia Dortmund 3-1 in their Champions League opener while Apoel were hammered 3-0 by defending champions Real Madrid.
(Reporting by Shrivathsa Sridhar in Bengaluru; editing by Sudipto Ganguly)
