No other team in Europe have been more haunted by Ibrahimovic, who has scored three hat tricks against the French club, including one in the first leg that put United on the brink of qualification with a 3-0 win.
Ibrahimovic has scored 17 goals against St Etienne in 14 games.
"Ibrahimovic's statistics against us are outstanding, he is a great player," St Etienne midfielder Romain Hamouma told a news conference on Tuesday. "However, we cannot be obsessed by just one player."
St Etienne coach Christophe Galtier said United could inflict damage through any number of players.
"You can have an anti-Ibrahimovic plan or an anti-Paul-Pogba plan but with this team danger can come from anywhere," said Galtier.
St Etienne go into the match as underdogs and Galtier said his team would need to seize their chances with the home fans behind them.
"We need a great start. We will have chances like in the first leg but this time we will have to convert them," he said.
Manchester United coach Jose Mourinho, who has to make do without the injured Wayne Rooney, is taking nothing for granted as he knows Geoffroy Guichard is one of the most atmospheric stadiums in Europe.
"I played here with Porto and I came later for St Etienne versus Lyon, as I was getting Lyon in the Champions League draw. I know the stadium, it is more beautiful now," he told a news conference.
"I know the atmosphere. I know tomorrow it will be amazing to play. Everyone likes that. I don't like to breathe the smoke. I don't think the players like to breath the smoke."
"It is a big atmosphere, a great atmosphere, maybe the greatest in France and we know their fans will motivate them very well," said forward Anthony Martial, who played in the stadium when he was at Monaco.
"We need to keep our focus and score a goal that will end their hopes of qualification."
(Writing by Julien Pretot; Editing by Richard Lough and Clare Fallon)
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