"I have been asked whether this is a good time to play them but I am always wary of that because these type of clubs more often than not bounce back emphatically," Hughes told reporters on Tuesday.
"We are certainly taking nothing for granted because we are fully aware as to how difficult a challenge they will pose to us on Boxing Day (Dec. 26)," he added.
Hughes, who won the league twice as a Manchester United player, said he was aware that the Old Trafford team was in a transitory phase and that a club of their stature have the players and coaching staff to turn things around.
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"Manchester United will know themselves that they are in a period of transition and are in a different cycle now," the Welshman added.
"Maybe they will have to wait until they are back at the level they were at before.
"They have top players and they have a manager who has managed at the very highest level. They will click again I am sure, but hopefully we won't allow it to be at the weekend."
Stoke, who are 11th in the table after 17 games, welcome fifth-placed United to the Britannia Stadium on Saturday.
(Reporting by Nayan Das in Bengaluru)
