"I have made the decision to retire from international football," said Robson-Kanu, who made his Wales debut in 2010.
"Long thought, but a decision made; commitments to my family and dedicating what time I have available to them and choosing to focus on my club career within sport and time needed away from the game."
Robson-Kanu and Aston Villa defender Neil Taylor were the notable absentees from Ryan Giggs' Wales squad to face Ireland and Denmark in the Nations League next month.
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"I wish Ryan Giggs and the team continued success in the years to come, and appreciate his understanding and support, a new generation to continue building on what Gary Speed and Chris Coleman have set in place," the striker added.
(Reporting by Hardik Vyas in Bengaluru; Editing by Ken Ferris)
