A stunning goal from Davy Proepper made it 2-0 in the 51st minute before Juergen Locadia added a third goal as PSV kept their fifth successive clean sheet in the league.
Ajax Amsterdam, who are 20 points clear of third-placed Utrecht, visit Willem II Tilburg on Sunday.
Ruud Boymans scored two goals in four minutes as Utrecht won 4-0 at 10-man Heerenveen.
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Utrecht took an early lead through Andreas Ludwig and received a further boost when Heerenveen's Joey van den Berg was sent off in the 31st minute for a dangerous tackle.
Chris Kum grabbed the fourth goal near the end.
PEC Zwolle are seventh after a double from Stef Nijland helped them beat bottom club De Graafschap 2-1.
(Reporting by Mark Gleeson; Editing by Tony Jimenez)
