The Simpsons won't have any repeats of Hank Azaria voicing Apu.
The producers behind the show have issued a statement saying that from now on, its characters of colour will be voiced by actors of colour only.
"Moving forward, The Simpsons will no longer have white actors voice non-white characters," the statement read.
News of the decision comes less than an hour after Mike Henry announced he will no longer voice the character of Cleveland Brown on fellow Fox animated comedy Family Guy.
The Simpsons has been subject to heavy criticism over the last few years on this issue, most notably over Azaria playing the Indian character Apu, and this statement represents a substantial shift from the producers' historical stance on the matter.
Mr Azaria announced that he was stepping away from voicing the character in January. Calls for him to do so intensified following the 2017 documentary The Problem With Apu, from comedian Hari Kondabolu.
The documentary explored how people of South Asian descent felt about growing up with Apu as one of their only representatives on American television.
The Simpsons added Kevin Michael Richardson, who had been previously been a recurring cast member, to the full-time cast a few seasons ago. Mr Richardson currently voices many of the show's African American characters.
The animated series space is currently having a reckoning with its history of casting white actors to play non-white characters.
In the last week alone, Jenny Slate announced on that she would no longer play the "bi-racial" character Missy on the popular Netflix show Big Mouth, and Kristen Bell revealed that she would be stepping down from her role as a "bi-racial" character in the Apple animated series Central Park.
