Thousands of protesters marched in central Athens, as unions challenged harsh austerity measures in Greece by holding their fourth general strike this year.
Members of a communist-backed labor union staged an occupation of the Labour Ministry. More than 5,000 protesters chanting "Don't bow your heads" filed past the ministry, while thousands more gathered for the day's main rally to parliament.
Store owners closed up and lowered protective shutters before the march got under way.
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Police deployed 1,700 officers and detained 36 people in an early show of force after violent protests two weeks ago left three people dead in a bank fire.
The strike closed schools, halted ferries and trains, and kept hospitals running on emergency staff.
Unions are protesting harsh measures imposed by the cash-strapped government.
Crippling debt crisis
During Greece's last general strike on May 5, three workers - including a pregnant woman - died when a bank was torched by rioters.
Public anger has grown against deep pension and salary cuts, as well as steep tax hikes, imposed in an attempt to pull Greece out of an unprecedented debt crisis.
The measures were needed for Greece to receive a E110 billion ($A161.31 billion) three-year rescue loan package from other EU countries and the International Monetary Fund that staved off bankruptcy.
But unions argue low-earners will suffer disproportionately from the measures.
"When will construction workers retire, at age 80?" Communist Party lawmaker Haralambos Haralambous asked. "How do you expect him to carry a bag of cement on his back until that age?"
Thursday's major strike - the fourth this year - affected all public and many private employers.
Fears of vandalism
However, unlike other general walkouts, most flights were unaffected as air traffic controllers stayed on the job. Some small regional airports closed, and Greece's Olympic Air carrier said it was cancelling 30 domestic flights.
About 5,000 protesters also marched in Greece's second city, Thessaloniki.
Greece's largest traders association urged the government to take appropriate police measures to prevent damage to stores which are frequently vandalised during protest marches.
The country's debt crisis has sent shock waves through global markets.
That, combined with fears for Europe's struggling economy and German warnings that the future of the euro is at stake, sent the common currency to a four-year low against the dollar on Wednesday.
Warding off bankruptcy, Greece on Wednesday repaid 10-year state bonds worth E8.5 billion ($A12.47 billion) after receiving the rescue loans.
