Three people are dead, including a man shot by police, after a stabbing rampage through Melbourne's inner east.
Police say the "random act of senseless violence" appears to have started about 10.40pm on Wednesday.
A protective services officer at Jolimont train station was approached by a stranger and stabbed, receiving non-life threatening cuts to his face.
Police say the attacker then got on a train and soon after, two women were found in a car at Hawthorn about 11.20pm with life-threatening stab wounds.
One woman died and the other is fighting for life.
Police were then called to reports of a man stabbed at Kew about 12.15am on Thursday.
That man died in hospital, while a second man was found near the crime scene.
Police tried to arrest the second man aged in his early 30s, but he was killed when officers fired their guns.
"There is nothing to suggest at this stage this is nothing less than a random act of senseless violence," Assistant Commissioner Glenn Weir told reporters at the scene.
Investigators are now trying to piece together what happened between the attacks.
Mr Weir has told 3AW radio at this stage there is "zero evidence" to indicate it is a terror-related event.
"This is a terrible event, this is something that's just shocking," he said.
Roads at Kew and Jolimont station remain closed.
Police are not searching for anyone else and the community is not at risk.
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