- October 4, 1957: First artificial satellite, Sputnik I, is launched by Soviet Union.
- April 12, 1961: Soviet cosmonaut Yuri Gagarin completes the first manned space flight, orbiting the Earth in 108 minutes.
- May 5, 1961: US launches first American astronaut, Alan Shepard Jr, into space, on a 15-minute, 22-second suborbital flight.
- May 25, 1961: President Kennedy declares the US space objective to put a man on the moon and return him safely by the end of the decade.
- February 20, 1962: John Glenn becomes first American to orbit Earth, completing three orbits.
- June 16-19, 1963: Cosmonaut Valentina Tereshkova, the first woman in space, completes 48 orbits.
- March 18, 1965: Cosmonaut Aleksei Leonov takes man's first space walk.
- January 27, 1967: Astronauts Gus Grissom, Edward White and Roger Chaffee die when a fire sweeps the Apollo I command module during a ground test at Kennedy Space Centre.
- April 24, 1967: Cosmonaut Vladimir Komarov is killed when his Soyuz I spacecraft crashes on return to Earth.
- December 21, 1968: First manned spacecraft to orbit moon, Apollo 8, comes within 112km of lunar surface.
- July 20, 1969: Man walks on the moon. Neil Armstrong and Edwin "Buzz" Aldrin of Apollo XI spend 21 1/2 hours on the moon, 2 1/2 of those outside the capsule.
- June 29, 1971 - Three cosmonauts, Georgy Dobrovolsky, Vladislav Volkov and Viktor Patsayev, die during re-entry of their Soyuz 11 spacecraft. A government commission disclosed that the three died 30 minutes before landing because a faulty valve depressurised the spacecraft.
- December 7-19, 1972: Apollo 17 mission that includes the longest and last stay of man on the moon - 74 hours, 59 minutes - by astronauts Eugene Cernan and Harrison Schmitt.
- May 14, 1973: Skylab I, first US orbiting laboratory, launched.
- July 17-19, 1975: US astronauts and Soviet cosmonauts participate in Apollo-Soyuz Test Project, docking together in space for two days.
- April 12, 1981: Shuttle Columbia becomes first winged spaceship to orbit Earth and return to airport landing.
- June 18, 1983: Sally Ride becomes first American woman in space.
- February 7, 1984: Astronaut Bruce McCandless performs man's first untethered spacewalk with a Manned Manoeuvreing Unit off the Challenger space shuttle.
- January 28, 1986: Challenger shuttle explodes 73 seconds after launch, killing its crew of seven.
- November 15, 1988 - Soviets launch their first space shuttle. The 3-hour, 20-minute flight of the shuttle Buran is unmanned.
- December 21, 1988 - Cosmonauts Vladimir Titov and Musa Manarov return to Earth from Soviet space station Mir after man's longest space flight - 365 days, 22 hours, 39 minutes.
- March 14, 1995: Norman Thagard becomes first American to be launched on a Russian rocket. Two days later, he becomes first American to visit the Russian space station Mir.
- June 29, 1995: Atlantis docks with Mir in first shuttle-station hook-up.
- September 26, 1996: Shannon Lucid returns to Earth after 188-day Mir mission, a US space endurance record and a world record for women.
- October 29, 1998: Glenn, now 77, returns to space aboard shuttle Discovery, becoming the oldest person ever to fly in space.
- May 29, 1999: Discovery becomes first shuttle to dock with the international space station, a multinational, permanent, orbiting research laboratory.
- November 2, 2000: An American and Russian crew begins living aboard the international space station.
- February 1, 2003: Shuttle Columbia breaks apart over Texas, 16 minutes before it was supposed to land in Florida.
- July 21, 2011 - Final space shuttle mission ends when Atlantis arrives at Kennedy Space Centre.
