Super Bowl champions the New England Patriots avoided a second defeat of the NFL season in dramatic fashion with a last-gasp 36-33 victory over the Houston Texans.
Trailing 33-28 with 30 seconds remaining, quarterback Tom Brady found Brandin Cooks in the end zone for the wide receiver's second touchdown of the game.
Brady threw for 378 yards and five touchdowns as the Patriots improved to 2-1.
Rookie quarterback Deshaun Watson threw for 301 yards and two touchdowns for the Texans.
The Atlanta Falcons, who squandered a 28-3 lead against the Patriots in last February's Super Bowl, maintained their 100 per cent start to the season with a hard-fought 30-26 win over the previously unbeaten Detroit Lions.
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The Denver Broncos surrendered their unbeaten season start losing 26-16 on the road to the Buffalo Bills, while the Pittsburgh Steelers also suffered their first loss of the season against the Chicago Bears 23-17.
The New York Giants and Philadelphia Eagles were also heading to overtime until Jake Elliott kicked a 61-yard field goal as the clock expired to give the Eagles a 27-24 win, with Eli Manning's three touchdown passes in the fourth quarter proving in vain.
In Minnesota, Case Keenum produced a brilliant display in place of the injured Sam Bradford, passing for three touchdowns and a career-high 369 yards without a turnover to guide the Vikings to a 34-17 victory over the Tampa Bay Buccaneers.
And it was also a tale of two quarterbacks in Carolina, where Cam Newton threw three interceptions and Drew Brees for three touchdowns as the New Orleans Saints cruised to a 34-13 win over the Panthers.
In a battle between two teams without a win, the Indianapolis Colts held off a late fightback from the Cleveland Browns to win 31-28, while the New York Jets also got off the mark with a 20-6 home win over the Miami Dolphins.
