The club already have a long-term agreement in place with the National Football League (NFL) to host regular seasons games at the stadium, and club chairman Daniel Levy said they had aspirations for the stadium to be a "multi-use venue".
"We look forward to welcoming Saracens and their fans to Tottenham and delivering world-class rugby matchday experiences, showcasing our new stadium and all the surrounding area has to offer," Levy said in a statement.
Saracens, the reigning Premiership champions, have used Wembley Stadium in the past for this game, which usually takes place in March during the international soccer break.
"For me and Saracens, it's a really special opportunity for us to partner with our fellow north Londoners," Saracens chairman Nigel Wray said.
"Together with Spurs we have the opportunity to create something very special in north London."
(Reporting by Rohith Nair in Bengaluru; Editing by Hugh Lawson)
