South Africa have selected uncapped Andile Phehlukwayo and Aiden Markram for next week's first Test against Bangladesh in Potchefstroom.
Both were part of the South African squad who lost 3-1 earlier this year in England, with the 22-year-old Markram set to be the latest to try to solve the troublesome opening position alongside Dean Elgar.
The right-handed batsman captained South Africa to victory at the 2014 under-19 World Cup.
"Aiden has been knocking on the door for some time now," Cricket South Africa national selection panel convener Linda Zondi said on Friday in a statement.
"He gained valuable insight into the Proteas' team culture during the tour of England and he has shown maturity beyond his years."
Phehlukwayo will vie with the more-experienced Wayne Parnell for the allrounder's position, although the latter faces a fitness test, with Chris Morris also ruled out with injury.
South Africa are also missing seamers Dale Steyn and Vernon Philander through injury.
The opening Test, which starts on Thursday at Senwes Park, is the first fixture in charge for new coach Ottis Gibson.
The second and final Test will be played from October 6-10 in Bloemfontein.
South Africa squad:
Faf du Plessis (capt), Hashim Amla, Temba Bavuma, Theunis de Bruyn, Quinton de Kock, Dean Elgar, Keshav Maharaj, Aiden Markram, Morne Morkel, Duanne Olivier, Wayne Parnell, Andile Phehlukwayo, Kagiso Rabada.
