"I think it is a difficult group because we have to face a difficult opponent, but we are still in the race. We have an important game against Feyenoord and have to win. We'll prepare to make sure we're ready," Darmian told MUTV.
United lost 1-0 to Feyenoord in Rotterdam in September but are on a 13-game unbeaten streak at home in Europe, last losing to Real Madrid at Old Trafford in the 2012-13 season.
"I remember (playing Feyenoord away) because it was not a good game for us. We have to change this and win our away games, but for now we’re playing at home and maybe that is a little bit easier," Italian Darmian added.
Feyenoord, who have not won in their last three European away games, will be without experienced midfielder Karim El Ahmadi after his troublesome foot injury flared up again.
The Dutch-born Morocco international returned in Sunday's 3-0 win over PEC Zwolle after three weeks out but had to go off when his foot hurt again not long after he got the second goal.
Feyenoord are also without Netherlands defender Terence Kongolo (hamstring) as well as Eric Botteghin, who is suspended after being sent off in their last Europa League game at Zorya.
The Europa League is the only major title United have not won and Darmian said the competition had become more attractive since the winners were guaranteed a Champions League spot.
United are sixth in the Premier League after 12 games, two places and six points below the Champions League spots.
"I think it (the Europa league) is a big competition. (Winning it) gives us a big opportunity to get into the Champions League which is crucial for a club like Manchester United," Darmian said.
(Reporting by Debanjan Bose in Bengaluru; additional reporting by Mark Gleeson; editing by Ken Ferris)
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