"He (Cavani) underwent a scan and it was decided he would not play in the friendly against Italy because of a hamstring strain," the AUF said on their website. (www.auf.org.uy)
The 30-year-old scored 49 goals in 50 games to help French side Paris St Germain secure a second-placed league finish last season.
Fellow striker Luis Suarez had also been ruled out of Uruguay's friendlies after sustaining a hamstring injury while training with his club Barcelona last month.
(Reporting by Aditi Prakash in Bengaluru; editing by Amlan Chakraborty)
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