After the latest massacre, at the Sandy Hook Elementary School, President Barack Obama appeared on television with tears in his eyes to make an emotional plea for "meaningful action" in the wake of the latest outrage.
"As a country we have been through this too many times," Obama said, mentioning earlier shooting massacres, in Colorado, Oregon and Wisconsin.
News that makes sense
Your trusted source for staying up-to-date with the world around you. Get free daily news updates and analysis, straight to your inbox.
Earlier, though, White House spokesman Jay Carney declined to discuss the political fallout, telling reporters this was a day "to feel enormous sympathy for families that are affected".
But congressman Jerrold Nadler, a Democrat, immediately responded: "If now is not the time to have a serious discussion about gun control and the epidemic of gun violence plaguing our society, I don't know when is."
"Yet another unstable person has gotten access to firearms and committed an unspeakable crime against innocent children. We cannot simply accept this as a routine product of modern American life," he said.
"I am challenging President Obama, the Congress, and the American public to act on our outrage and, finally, do something about this."
Obama's presidency has been marred by several mass killings since 2009, including a 2011 attack on Democratic congresswoman Gabrielle Giffords, who survived a point blank shot to the head, and a rampage at a Colorado movie theatre in July that left 12 dead, including the shooter.
After a massacre this summer that killed six people at a Sikh temple, the White House rejected the idea of new gun control legislation.
Obama's position was that the administration would do everything in its power to keep guns out of the hands of criminals and unstable individuals, while protecting Americans' constitutional right to bear arms.
The constitution's Second Amendment is defended tooth and nail by the US gun lobby, which has been successful in blunting past drives to restrict the sale of high-powered weapons.
To change the laws, Obama needs Congress to act, and so far the Republican opposition has blocked all reforms of the federal gun laws, including a return of the ban on assault rifles passed under president Bill Clinton but which expired in 2004 under president George W Bush.
The US media has once again revived the debate, as it did after the killings in Aurora, Colorado this summer and earlier this week after three people were killed in a shooting at an Oregon shopping mall.
"Today is not the day to talk about the politics," USA Today's Washington bureau chief Susan Page told news website Politico. "Is this the tipping point? I don't know the answer to that."
"There has got to be some kind of measurable change, some kind of reaction," said Alex Wagner, an anchor at MSNBC.
"One would hope that there will be some political capital to reform the way in which we handle gun and gun violence in this country."
But defenders of the Second Amendment are unmoved. Just as after previous killings, they insist that restrictions on the sale of semi-automatic weapons is not the solution.
"There's a good side of guns and you can't forget about either," said Alan Gottlieb, the head of the Second Amendment Foundation, said.
"There was nobody in that school who was allowed to have a firearm to protect themselves or those children. And I find that to be deplorable."
"I'm sure the person who committed this horrible act knew he could go in and do it because no one else could have a gun. He didn't care about the law because he was going to break it anyway," he said.
