"The player is already resting and will be discharged from hospital on Tuesday," said Valencia in a statement.
"His recovery is estimated to take between three and four weeks depending on how the situation develops."
Guedes, on loan from Paris St Germain, has been crucial in Valencia's climb to second in the standings, four points behind leaders Barca.
Centre back Ezequiel Garay suffered an abdominal muscle problem during Sunday's game and the club are monitoring him ahead of the King's Cup last 32 second leg tie at home to Real Zaragoza on Thursday, in which Valencia hold a 2-0 lead.
(Reporting by Rik Sharma in Madrid; Editing by Ken Ferris)
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