Conjoined 14-month-old twins are flying to Melbourne from Bhutan in a bid to be separated and given a chance to live.
Nima and Dawa Pelden will undergo surgery at the Royal Children's Hospital after a fundraising effort by the Children First foundation, News Corp Australia reports.
The bid comes nine years after the foundation and the hospital successfully separated Bangladeshi sisters Trishna and Krishna.
The girls are expected to arrive in Melbourne on Tuesday.
Bhutan is a landlocked country, isolated at the foothills of the Himalayan mountains with a population of about 775,000.
The southern Asian nation is known for measuring its gross national happiness as a way of gauging its people's prosperity.
