"The injury will restrict Webb's involvement in the campaign and further assessments are required to establish the best course of action."
The omission of the 29-year-old Webb was the latest injury setback for Wales ahead of their opening match against Scotland in Cardiff on Feb. 3.
Warren Gatland's team were already facing issues in their back line with experienced flyhalves Dan Biggar (shoulder) and Rhys Priestland (hamstring) ruled out of the opening Six Nations games.
Uncapped Cardiff scrumhalf Tomos Williams has been called into the squad.
(Reporting by Hardik Vyas in Bengaluru, editing by Ed Osmond)
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